Discovery of Potent N-Ethylurea Pyrazole Derivatives as Dual Inhibitors of Trypanosoma brucei and Trypanosoma cruzi

[Image: see text] Trypanosoma brucei (T. brucei) and Trypanosoma cruzi (T. cruzi) are causative agents of parasitic diseases known as human African trypanosomiasis and Chagas disease, respectively. Together, these diseases affect 68 million people around the world. Current treatments are unsatisfact...

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Опубликовано в: :ACS Med Chem Lett
Главные авторы: Varghese, Swapna, Rahmani, Raphaël, Russell, Stephanie, Deora, Girdhar Singh, Ferrins, Lori, Toynton, Arthur, Jones, Amy, Sykes, Melissa, Kessler, Albane, Eufrásio, Amanda, Cordeiro, Artur Torres, Sherman, Julian, Rodriguez, Ana, Avery, Vicky M., Piggott, Matthew J., Baell, Jonathan B.
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2019
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7073874/
https://ncbi.nlm.nih.gov/pubmed/32184957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00218
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