Discovery of Potent N-Ethylurea Pyrazole Derivatives as Dual Inhibitors of Trypanosoma brucei and Trypanosoma cruzi

[Image: see text] Trypanosoma brucei (T. brucei) and Trypanosoma cruzi (T. cruzi) are causative agents of parasitic diseases known as human African trypanosomiasis and Chagas disease, respectively. Together, these diseases affect 68 million people around the world. Current treatments are unsatisfact...

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Pubblicato in:ACS Med Chem Lett
Autori principali: Varghese, Swapna, Rahmani, Raphaël, Russell, Stephanie, Deora, Girdhar Singh, Ferrins, Lori, Toynton, Arthur, Jones, Amy, Sykes, Melissa, Kessler, Albane, Eufrásio, Amanda, Cordeiro, Artur Torres, Sherman, Julian, Rodriguez, Ana, Avery, Vicky M., Piggott, Matthew J., Baell, Jonathan B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2019
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7073874/
https://ncbi.nlm.nih.gov/pubmed/32184957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00218
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