Discovery of Potent N-Ethylurea Pyrazole Derivatives as Dual Inhibitors of Trypanosoma brucei and Trypanosoma cruzi

[Image: see text] Trypanosoma brucei (T. brucei) and Trypanosoma cruzi (T. cruzi) are causative agents of parasitic diseases known as human African trypanosomiasis and Chagas disease, respectively. Together, these diseases affect 68 million people around the world. Current treatments are unsatisfact...

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Bibliografiska uppgifter
I publikationen:ACS Med Chem Lett
Huvudupphovsmän: Varghese, Swapna, Rahmani, Raphaël, Russell, Stephanie, Deora, Girdhar Singh, Ferrins, Lori, Toynton, Arthur, Jones, Amy, Sykes, Melissa, Kessler, Albane, Eufrásio, Amanda, Cordeiro, Artur Torres, Sherman, Julian, Rodriguez, Ana, Avery, Vicky M., Piggott, Matthew J., Baell, Jonathan B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2019
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7073874/
https://ncbi.nlm.nih.gov/pubmed/32184957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00218
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