Discovery of Potent N-Ethylurea Pyrazole Derivatives as Dual Inhibitors of Trypanosoma brucei and Trypanosoma cruzi

[Image: see text] Trypanosoma brucei (T. brucei) and Trypanosoma cruzi (T. cruzi) are causative agents of parasitic diseases known as human African trypanosomiasis and Chagas disease, respectively. Together, these diseases affect 68 million people around the world. Current treatments are unsatisfact...

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Publicado en:ACS Med Chem Lett
Main Authors: Varghese, Swapna, Rahmani, Raphaël, Russell, Stephanie, Deora, Girdhar Singh, Ferrins, Lori, Toynton, Arthur, Jones, Amy, Sykes, Melissa, Kessler, Albane, Eufrásio, Amanda, Cordeiro, Artur Torres, Sherman, Julian, Rodriguez, Ana, Avery, Vicky M., Piggott, Matthew J., Baell, Jonathan B.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2019
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7073874/
https://ncbi.nlm.nih.gov/pubmed/32184957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00218
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