Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3

af Tsukumo, Yoshinori, Alain, Tommy, Fonseca, Bruno D., Nadon, Robert, Sonenberg, Nahum
Udgivet i Nat Commun (2016)

LARP1 and LARP4: up close with PABP for mRNA 3’ poly(A) protection and stabilization

af Mattijssen, Sandy, Kozlov, Guennadi, Fonseca, Bruno D., Gehring, Kalle, Maraia, Richard J.
Udgivet i RNA Biol (2021)

LARP1 on TOP of Ribosome Production

af Fonseca, Bruno D., Lahr, Roni M., Damgaard, Christian K., Alain, Tommy, Berman, Andrea J.
Udgivet i Wiley Interdiscip Rev RNA (2018)

The isolated La-module of LARP1 mediates 3’ poly(A) protection and mRNA stabilization, dependent on its intrinsic PAM2 binding to PABPC1

af Mattijssen, Sandy, Kozlov, Guennadi, Gaidamakov, Sergei, Ranjan, Amitabh, Fonseca, Bruno D., Gehring, Kalle, Maraia, Richard J.
Udgivet i RNA Biol (2020)

Re-evaluating the Roles of Proposed Modulators of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling

af Wang, Xuemin, Fonseca, Bruno D., Tang, Hua, Liu, Rui, Elia, Androulla, Clemens, Michael J., Bommer, Ulrich-Axel, Proud, Christopher G.
Udgivet 2008

Regulation of mTORC1 Signaling by pH

af Balgi, Aruna D., Diering, Graham H., Donohue, Elizabeth, Lam, Karen K. Y., Fonseca, Bruno D., Zimmerman, Carla, Numata, Masayuki, Roberge, Michel
Udgivet 2011

Screen for Chemical Modulators of Autophagy Reveals Novel Therapeutic Inhibitors of mTORC1 Signaling

af Balgi, Aruna D., Fonseca, Bruno D., Donohue, Elizabeth, Tsang, Trevor C. F., Lajoie, Patrick, Proud, Christopher G., Nabi, Ivan R., Roberge, Michel
Udgivet 2009

Capturing the Mechanism Underlying TOP mRNA Binding to LARP1

af Cassidy, Kevin C., Lahr, Roni M., Kaminsky, Jesse C., Mack, Stephanie, Fonseca, Bruno D., Das, Subha R., Berman, Andrea J., Durrant, Jacob D.
Udgivet i Structure (2019)

Pharmacological and Genetic Evaluation of Proposed Roles of Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase (MEK), Extracellular Signal-regulated Kina...

af Fonseca, Bruno D., Alain, Tommy, Finestone, Leona K., Huang, Brandon P. H., Rolfe, Mark, Jiang, Tian, Yao, Zhong, Hernandez, Greco, Bennett, Christopher F., Proud, Christopher G.
Udgivet 2011

La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs

af Lahr, Roni M, Fonseca, Bruno D, Ciotti, Gabrielle E, Al-Ashtal, Hiba A, Jia, Jian-Jun, Niklaus, Marius R, Blagden, Sarah P, Alain, Tommy, Berman, Andrea J
Udgivet i eLife (2017)

The Protozoan Parasite Toxoplasma gondii Selectively Reprograms the Host Cell Translatome

af Leroux, Louis-Philippe, Lorent, Julie, Graber, Tyson E., Chaparro, Visnu, Masvidal, Laia, Aguirre, Maria, Fonseca, Bruno D., van Kempen, Léon C., Alain, Tommy, Larsson, Ola, Jaramillo, Maritza
Udgivet i Infect Immun (2018)

mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs

af Dowling, Ryan J. O., Topisirovic, Ivan, Alain, Tommy, Bidinosti, Michael, Fonseca, Bruno D., Petroulakis, Emmanuel, Wang, Xiaoshan, Larsson, Ola, Selvaraj, Anand, Liu, Yi, Kozma, Sara C., Thomas, George, Sonenberg, Nahum
Udgivet 2010

Structure-Activity Analysis of Niclosamide Reveals Potential Role for Cytoplasmic pH in Control of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling

af Fonseca, Bruno D., Diering, Graham H., Bidinosti, Michael A., Dalal, Kush, Alain, Tommy, Balgi, Aruna D., Forestieri, Roberto, Nodwell, Matt, Rajadurai, Charles V., Gunaratnam, Cynthia, Tee, Andrew R., Duong, Franck, Andersen, Raymond J., Orlowski, John, Numata, Masayuki, Sonenberg, Nahum, Roberge, Michel
Udgivet 2012

A Novel 4EHP-GIGYF2 Translational Repressor Complex Is Essential for Mammalian Development

af Morita, Masahiro, Ler, Lian Wee, Fabian, Marc R., Siddiqui, Nadeem, Mullin, Michael, Henderson, Valerie C., Alain, Tommy, Fonseca, Bruno D., Karashchuk, Galina, Bennett, Christopher F., Kabuta, Tomohiro, Higashi, Shinji, Larsson, Ola, Topisirovic, Ivan, Smith, Robert J., Gingras, Anne-Claude, Sonenberg, Nahum
Udgivet 2012

The mTOR regulated RNA-binding protein LARP1 requires PABPC1 for guided mRNA interaction

af Smith, Ewan M, Benbahouche, Nour El Houda, Morris, Katherine, Wilczynska, Ania, Gillen, Sarah, Schmidt, Tobias, Meijer, Hedda A, Jukes-Jones, Rebekah, Cain, Kelvin, Jones, Carolyn, Stoneley, Mark, Waldron, Joseph A, Bell, Cameron, Fonseca, Bruno D, Blagden, Sarah, Willis, Anne E, Bushell, Martin
Udgivet i Nucleic Acids Res (2020)

La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)

af Fonseca, Bruno D., Zakaria, Chadi, Jia, Jian-Jun, Graber, Tyson E., Svitkin, Yuri, Tahmasebi, Soroush, Healy, Danielle, Hoang, Huy-Dung, Jensen, Jacob M., Diao, Ilo T., Lussier, Alexandre, Dajadian, Christopher, Padmanabhan, Niranjan, Wang, Walter, Matta-Camacho, Edna, Hearnden, Jaclyn, Smith, Ewan M., Tsukumo, Yoshinori, Yanagiya, Akiko, Morita, Masahiro, Petroulakis, Emmanuel, González, Jose L., Hernández, Greco, Alain, Tommy, Damgaard, Christian K.
Udgivet i J Biol Chem (2015)

S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3

af Wang, Fuan, Alain, Tommy, Szretter, Kristy J., Stephenson, Kyle, Pol, Jonathan G., Atherton, Matthew J., Hoang, Huy-Dung, Fonseca, Bruno D., Zakaria, Chadi, Chen, Lan, Rangwala, Zainab, Hesch, Adam, Chan, Eva Sin Yan, Tuinman, Carly, Suthar, Mehul S., Jiang, Zhaozhao, Ashkar, Ali A., Thomas, George, Kozma, Sara C., Gale, Michael, Fitzgerald, Katherine A., Diamond, Michael S., Mossman, Karen, Sonenberg, Nahum, Wan, Yonghong, Lichty, Brian D.
Udgivet i Nat Immunol (2016)

mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1

af Jia, Jian-Jun, Lahr, Roni M, Solgaard, Michael T, Moraes, Bruno J, Pointet, Roberta, Yang, An-Dao, Celucci, Giovanna, Graber, Tyson E, Hoang, Huy-Dung, Niklaus, Marius R, Pena, Izabella A, Hollensen, Anne K, Smith, Ewan M, Chaker-Margot, Malik, Anton, Leonie, Dajadian, Christopher, Livingstone, Mark, Hearnden, Jaclyn, Wang, Xu-Dong, Yu, Yonghao, Maier, Timm, Damgaard, Christian K, Berman, Andrea J, Alain, Tommy, Fonseca, Bruno D
Udgivet i Nucleic Acids Res (2021)