La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)

The mammalian target of rapamycin complex 1 (mTORC1) is a critical regulator of protein synthesis. The best studied targets of mTORC1 in translation are the eukaryotic initiation factor-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase 1 (S6K1). In this study, we identify the La-related pro...

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Publicat a:J Biol Chem
Autors principals: Fonseca, Bruno D., Zakaria, Chadi, Jia, Jian-Jun, Graber, Tyson E., Svitkin, Yuri, Tahmasebi, Soroush, Healy, Danielle, Hoang, Huy-Dung, Jensen, Jacob M., Diao, Ilo T., Lussier, Alexandre, Dajadian, Christopher, Padmanabhan, Niranjan, Wang, Walter, Matta-Camacho, Edna, Hearnden, Jaclyn, Smith, Ewan M., Tsukumo, Yoshinori, Yanagiya, Akiko, Morita, Masahiro, Petroulakis, Emmanuel, González, Jose L., Hernández, Greco, Alain, Tommy, Damgaard, Christian K.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
Protein Synthesis and Degradation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481205/
https://ncbi.nlm.nih.gov/pubmed/25940091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.621730
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