The isolated La-module of LARP1 mediates 3’ poly(A) protection and mRNA stabilization, dependent on its intrinsic PAM2 binding to PABPC1

The protein domain arrangement known as the La-module, comprised of a La motif (LaM) followed by a linker and RNA recognition motif (RRM), is found in seven La-related proteins: LARP1, LARP1B, LARP3 (La protein), LARP4, LARP4B, LARP6, and LARP7 in humans. Several LARPs have been characterized for th...

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Detalhes bibliográficos
Publicado no:RNA Biol
Main Authors: Mattijssen, Sandy, Kozlov, Guennadi, Gaidamakov, Sergei, Ranjan, Amitabh, Fonseca, Bruno D., Gehring, Kalle, Maraia, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7928023/
https://ncbi.nlm.nih.gov/pubmed/33292040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2020.1860376
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