Screen for Chemical Modulators of Autophagy Reveals Novel Therapeutic Inhibitors of mTORC1 Signaling

BACKGROUND: Mammalian target of rapamycin complex 1 (mTORC1) is a protein kinase that relays nutrient availability signals to control numerous cellular functions including autophagy, a process of cellular self-eating activated by nutrient depletion. Addressing the therapeutic potential of modulating...

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Главные авторы: Balgi, Aruna D., Fonseca, Bruno D., Donohue, Elizabeth, Tsang, Trevor C. F., Lajoie, Patrick, Proud, Christopher G., Nabi, Ivan R., Roberge, Michel
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2009
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742736/
https://ncbi.nlm.nih.gov/pubmed/19771169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007124
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