Nitazoxanide Stimulates Autophagy and Inhibits mTORC1 Signaling and Intracellular Proliferation of Mycobacterium tuberculosis

Tuberculosis, caused by Mycobacterium tuberculosis infection, is a major cause of morbidity and mortality in the world today. M. tuberculosis hijacks the phagosome-lysosome trafficking pathway to escape clearance from infected macrophages. There is increasing evidence that manipulation of autophagy,...

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Autors principals: Lam, Karen K. Y., Zheng, Xingji, Forestieri, Roberto, Balgi, Aruna D., Nodwell, Matt, Vollett, Sarah, Anderson, Hilary J., Andersen, Raymond J., Av-Gay, Yossef, Roberge, Michel
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349752/
https://ncbi.nlm.nih.gov/pubmed/22589723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002691
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