La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs

The 5’terminal oligopyrimidine (5’TOP) motif is a cis-regulatory RNA element located immediately downstream of the 7-methylguanosine [m(7)G] cap of TOP mRNAs, which encode ribosomal proteins and translation factors. In eukaryotes, this motif coordinates the synchronous and stoichiometric expression...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Lahr, Roni M, Fonseca, Bruno D, Ciotti, Gabrielle E, Al-Ashtal, Hiba A, Jia, Jian-Jun, Niklaus, Marius R, Blagden, Sarah P, Alain, Tommy, Berman, Andrea J
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Biochemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5419741/
https://ncbi.nlm.nih.gov/pubmed/28379136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.24146
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