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Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3
Targeting mTORC1 is a highly promising strategy in cancer therapy. Suppression of mTORC1 activity leads to rapid dephosphorylation of eIF4E-binding proteins (4E-BP1–3) and subsequent inhibition of mRNA translation. However, how the different 4E-BPs affect translation during prolonged use of mTOR inh...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4915159/ https://ncbi.nlm.nih.gov/pubmed/27319316 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11776 |
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