mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs

The mammalian target of rapamycin complex 1 (mTORC1) integrates mitogen and nutrient signals to control cell proliferation and cell size. Hence, mTORC1 is implicated in a large number of human diseases--including diabetes, obesity, heart disease, and cancer--that are characterized by aberrant cell g...

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Detalhes bibliográficos
Main Authors: Dowling, Ryan J. O., Topisirovic, Ivan, Alain, Tommy, Bidinosti, Michael, Fonseca, Bruno D., Petroulakis, Emmanuel, Wang, Xiaoshan, Larsson, Ola, Selvaraj, Anand, Liu, Yi, Kozma, Sara C., Thomas, George, Sonenberg, Nahum
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893390/
https://ncbi.nlm.nih.gov/pubmed/20508131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1187532
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