The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis

Translational control plays an important role in cell growth and tumorigenesis. Cap-dependent translation initiation of mammalian mRNAs with structured 5′UTRs requires the DExH-box protein, DHX29, in vitro. Here we show that DHX29 is important for translation in vivo. Down-regulation of DHX29 leads...

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Dettagli Bibliografici
Autori principali: Parsyan, Armen, Shahbazian, David, Martineau, Yvan, Petroulakis, Emmanuel, Alain, Tommy, Larsson, Ola, Mathonnet, Geraldine, Tettweiler, Gritta, Hellen, Christopher U., Pestova, Tatyana V., Svitkin, Yuri V., Sonenberg, Nahum
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799747/
https://ncbi.nlm.nih.gov/pubmed/20018725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909773106
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