Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production

Oncolytic viruses constitute a promising therapy against malignant gliomas (MGs). However, virus-induced type I IFN greatly limits its clinical application. The kinase mammalian target of rapamycin (mTOR) stimulates type I IFN production via phosphorylation of its effector proteins, 4E-BPs and S6Ks....

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Detalhes bibliográficos
Main Authors: Alain, Tommy, Lun, XueQing, Martineau, Yvan, Sean, Polen, Pulendran, Bali, Petroulakis, Emmanuel, Zemp, Franz J., Lemay, Chantal G., Roy, Dominic, Bell, John C., Thomas, George, Kozma, Sara C., Forsyth, Peter A., Costa-Mattioli, Mauro, Sonenberg, Nahum
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824402/
https://ncbi.nlm.nih.gov/pubmed/20080710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912344107
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