Re-evaluating the Roles of Proposed Modulators of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling

Signaling through mammalian target of rapamycin complex 1 (mTORC1) is stimulated by amino acids and insulin. Insulin inactivates TSC1/2, the GTPase-activator complex for Rheb, and Rheb·GTP activates mTORC1. It is not clear how amino acids regulate mTORC1. FKBP38 (immunophilin FK506-binding protein,...

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Detalhes bibliográficos
Principais autores: Wang, Xuemin, Fonseca, Bruno D., Tang, Hua, Liu, Rui, Elia, Androulla, Clemens, Michael J., Bommer, Ulrich-Axel, Proud, Christopher G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662142/
https://ncbi.nlm.nih.gov/pubmed/18676370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803348200
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