S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3

Cytosolic DNA-mediated activation of the transcription factor IRF3 is a key event in host antiviral responses. Here, we show that infection of DNA viruses induced the interaction of the mTOR downstream effector S6K1 (S6 kinase 1) and the signaling adaptor STING in a cGAS (cGAMP synthase)-dependent m...

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Publicado no:Nat Immunol
Main Authors: Wang, Fuan, Alain, Tommy, Szretter, Kristy J., Stephenson, Kyle, Pol, Jonathan G., Atherton, Matthew J., Hoang, Huy-Dung, Fonseca, Bruno D., Zakaria, Chadi, Chen, Lan, Rangwala, Zainab, Hesch, Adam, Chan, Eva Sin Yan, Tuinman, Carly, Suthar, Mehul S., Jiang, Zhaozhao, Ashkar, Ali A., Thomas, George, Kozma, Sara C., Gale, Michael, Fitzgerald, Katherine A., Diamond, Michael S., Mossman, Karen, Sonenberg, Nahum, Wan, Yonghong, Lichty, Brian D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4917298/
https://ncbi.nlm.nih.gov/pubmed/27043414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3433
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