Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research?

le De Vos, Kurt J., Hafezparast, Majid
Foilsithe in Neurobiol Dis (2017)

Expression of Phosphatidylinositol (4,5) Bisphosphate–specific Pleckstrin Homology Domains Alters Direction But Not the Level of Axonal Transport of Mitochondria

le De Vos, Kurt J., Sable, Julia, Miller, Kyle E., Sheetz, Michael P.
Foilsithe 2003

Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?

le Webster, Christopher P., Smith, Emma F., Shaw, Pamela J., De Vos, Kurt J.
Foilsithe in Front Mol Neurosci (2017)

C9orf72 plays a central role in Rab GTPase-dependent regulation of autophagy

le Webster, Christopher P., Smith, Emma F., Grierson, Andrew J., De Vos, Kurt J.
Foilsithe in Small GTPases (2016)

Phosphorylation of kinesin light chain 1 at serine 460 modulates binding and trafficking of calsyntenin-1

le Vagnoni, Alessio, Rodriguez, Lilia, Manser, Catherine, De Vos, Kurt J., Miller, Christopher C. J.
Foilsithe 2011

Amyotrophic lateral sclerosis-associated mutant SOD1 inhibits anterograde axonal transport of mitochondria by reducing Miro1 levels

le Moller, Annekathrin, Bauer, Claudia S, Cohen, Rebecca N, Webster, Christopher P, De Vos, Kurt J
Foilsithe in Hum Mol Genet (2017)

Deficiency of the Copper Chaperone for Superoxide Dismutase Increases Amyloid-β Production

le Gray, Emma H., De Vos, Kurt J., Dingwall, Colin, Perkinton, Michael S., Miller, Christopher C.J.
Foilsithe 2010

Axonal Transport Defects in a Mitofusin 2 Loss of Function Model of Charcot-Marie-Tooth Disease in Zebrafish

le Chapman, Anna L., Bennett, Ellen J., Ramesh, Tennore M., De Vos, Kurt J., Grierson, Andrew J.
Foilsithe 2013

Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria

le Mórotz, Gábor M., De Vos, Kurt J., Vagnoni, Alessio, Ackerley, Steven, Shaw, Christopher E., Miller, Christopher C.J.
Foilsithe 2012

A comparison of in vitro properties of resting SOD1 transgenic microglia reveals evidence of reduced neuroprotective function

le Sargsyan, Siranush A, Blackburn, Daniel J, Barber, Siân C, Grosskreutz, Julian, De Vos, Kurt J, Monk, Peter N, Shaw, Pamela J
Foilsithe 2011

Lemur tyrosine kinase-2 signalling regulates kinesin light chain-2 phosphorylation and binding of Smad2 cargo

le Manser, Catherine, Guillot, Florence, Vagnoni, Alessio, Davies, Jennifer, Lau, Kwok-Fai, McLoughlin, Declan M., De Vos, Kurt J., Miller, Christopher C.J.
Foilsithe 2011

Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons

le Rodríguez-Martín, Teresa, Pooler, Amy M., Lau, Dawn H.W., Mórotz, Gábor M., De Vos, Kurt J., Gilley, Jonathan, Coleman, Michael P., Hanger, Diane P.
Foilsithe in Neurobiol Dis (2016)

VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis

le De Vos, Kurt J., Mórotz, Gábor M., Stoica, Radu, Tudor, Elizabeth L., Lau, Kwok-Fai, Ackerley, Steven, Warley, Alice, Shaw, Christopher E., Miller, Christopher C.J.
Foilsithe 2012

Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations

le Godena, Vinay K., Brookes-Hocking, Nicholas, Moller, Annekathrin, Shaw, Gary, Oswald, Matthew, Sancho, Rosa M., Miller, Christopher C. J., Whitworth, Alexander J., De Vos, Kurt J.
Foilsithe 2014

ALS/FTD‐associated FUS activates GSK‐3β to disrupt the VAPB–PTPIP51 interaction and ER–mitochondria associations

le Stoica, Radu, Paillusson, Sébastien, Gomez‐Suaga, Patricia, Mitchell, Jacqueline C, Lau, Dawn HW, Gray, Emma H, Sancho, Rosa M, Vizcay‐Barrena, Gema, De Vos, Kurt J, Shaw, Christopher E, Hanger, Diane P, Noble, Wendy, Miller, Christopher CJ
Foilsithe in EMBO Rep (2016)

The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy

le Webster, Christopher P, Smith, Emma F, Bauer, Claudia S, Moller, Annekathrin, Hautbergue, Guillaume M, Ferraiuolo, Laura, Myszczynska, Monika A, Higginbottom, Adrian, Walsh, Matthew J, Whitworth, Alexander J, Kaspar, Brian K, Meyer, Kathrin, Shaw, Pamela J, Grierson, Andrew J, De Vos, Kurt J
Foilsithe in EMBO J (2016)

C9ORF72 hexanucleotide repeat exerts toxicity in a stable, inducible motor neuronal cell model, which is rescued by partial depletion of Pten

le Stopford, Matthew J., Higginbottom, Adrian, Hautbergue, Guillaume M., Cooper-Knock, Johnathan, Mulcahy, Padraig J., De Vos, Kurt J., Renton, Alan E., Pliner, Hannah, Calvo, Andrea, Chio, Adriano, Traynor, Bryan J., Azzouz, Mimoun, Heath, Paul R., Kirby, Janine, Shaw, Pamela J.
Foilsithe in Hum Mol Genet (2017)

ER–mitochondria associations are regulated by the VAPB–PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43

le Stoica, Radu, De Vos, Kurt J., Paillusson, Sébastien, Mueller, Sarah, Sancho, Rosa M., Lau, Kwok-Fai, Vizcay-Barrena, Gema, Lin, Wen-Lang, Xu, Ya-Fei, Lewis, Jada, Dickson, Dennis W., Petrucelli, Leonard, Mitchell, Jacqueline C., Shaw, Christopher E., Miller, Christopher C. J.
Foilsithe 2014

Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content

le De Vos, Kurt J., Chapman, Anna L., Tennant, Maria E., Manser, Catherine, Tudor, Elizabeth L., Lau, Kwok-Fai, Brownlees, Janet, Ackerley, Steven, Shaw, Pamela J., McLoughlin, Declan M., Shaw, Christopher E., Leigh, P. Nigel, Miller, Christopher C.J., Grierson, Andrew J.
Foilsithe in Hum Mol Genet (2007)

C9orf72 Expansion Disrupts ATM-mediated Chromosomal Break Repair

le Walker, Callum, Herranz-Martin, Saul, Karyka, Evangelia, Liao, Chunyan, Lewis, Katherine, Elsayed, Waheba, Lukashchuk, Vera, Chiang, Shih-Chieh, Ray, Swagat, Mulcahy, Padraig J., Jurga, Mateusz, Tsagakis, Ioannis, Iannitti, Tommaso, Chandran, Jayanth, Coldicott, Ian, De Vos, Kurt J., Hassan, Mohamed K., Higginbottom, Adrian, Shaw, Pamela J., Hautbergue, Guillaume M., Azzouz, Mimoun, El-Khamisy, Sherif F.
Foilsithe in Nat Neurosci (2017)