A comparison of in vitro properties of resting SOD1 transgenic microglia reveals evidence of reduced neuroprotective function

BACKGROUND: Overexpression of mutant copper/zinc superoxide dismutase (SOD1) in rodents has provided useful models for studying the pathogenesis of amyotrophic lateral sclerosis (ALS). Microglia have been shown to contribute to ALS disease progression in these models, although the mechanism of this...

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Detalhes bibliográficos
Main Authors: Sargsyan, Siranush A, Blackburn, Daniel J, Barber, Siân C, Grosskreutz, Julian, De Vos, Kurt J, Monk, Peter N, Shaw, Pamela J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191510/
https://ncbi.nlm.nih.gov/pubmed/21943126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-12-91
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