A comparison of in vitro properties of resting SOD1 transgenic microglia reveals evidence of reduced neuroprotective function

BACKGROUND: Overexpression of mutant copper/zinc superoxide dismutase (SOD1) in rodents has provided useful models for studying the pathogenesis of amyotrophic lateral sclerosis (ALS). Microglia have been shown to contribute to ALS disease progression in these models, although the mechanism of this...

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Bibliographic Details
Main Authors: Sargsyan, Siranush A, Blackburn, Daniel J, Barber, Siân C, Grosskreutz, Julian, De Vos, Kurt J, Monk, Peter N, Shaw, Pamela J
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191510/
https://ncbi.nlm.nih.gov/pubmed/21943126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-12-91
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