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Mutant SOD1 G93A microglia have an inflammatory phenotype and elevated production of MCP-1

The inflammatory response in amyotrophic lateral sclerosis (ALS) is well documented but the underlying cellular mechanisms have not been fully elucidated. We report that microglia isolated from the mutant human SOD1 G93A transgenic mouse model of ALS, have an increased response to the inflammatory s...

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Autors principals: Sargsyan, Siranush A., Blackburn, Daniel J., Barber, Siân C., Monk, Peter N., Shaw, Pamela J.
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889291/
https://ncbi.nlm.nih.gov/pubmed/19752764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/WNR.0b013e328331e8fa
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