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ALS-associated mutant SOD1(G93A )causes mitochondrial vacuolation by expansion of the intermembrane space and by involvement of SOD1 aggregation and peroxisomes
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is an age-dependent neurodegenerative disease that causes motor neuron degeneration, paralysis and death. Mutations in Cu, Zn superoxide dismutase (SOD1) are one cause for the familial form of this disease. Transgenic mice expressing mutant SOD1 develo...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2003
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC169170/ https://ncbi.nlm.nih.gov/pubmed/12864925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-4-16 |
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