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ALS-associated mutant SOD1(G93A )causes mitochondrial vacuolation by expansion of the intermembrane space and by involvement of SOD1 aggregation and peroxisomes

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is an age-dependent neurodegenerative disease that causes motor neuron degeneration, paralysis and death. Mutations in Cu, Zn superoxide dismutase (SOD1) are one cause for the familial form of this disease. Transgenic mice expressing mutant SOD1 develo...

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Autori principali: Higgins, Cynthia MJ, Jung, Cheolwha, Xu, Zuoshang
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC169170/
https://ncbi.nlm.nih.gov/pubmed/12864925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-4-16
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