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SOD1 targeted to the mitochondrial intermembrane space prevents motor neuropathy in the Sod1 knockout mouse

Motor axon degeneration is a critical but poorly understood event leading to weakness and muscle atrophy in motor neuron diseases. Here, we investigated oxidative stress-mediated axonal degeneration in mice lacking the antioxidant enzyme, Cu,Zn superoxide dismutase (SOD1). We demonstrate a progressi...

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Bibliografische gegevens
Hoofdauteurs: Fischer, Lindsey R., Igoudjil, Anissa, Magrané, Jordi, Li, Yingjie, Hansen, Jason M., Manfredi, Giovanni, Glass, Jonathan D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009841/
https://ncbi.nlm.nih.gov/pubmed/21078595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awq314
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