Arylsulfanyl Pyrazolones Block Mutant SOD1-G93A Aggregation. Potential Application for the Treatment of Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is an orphan neurodegenerative disease currently without a cure. Mutations in copper/zinc superoxide dismutase 1 (SOD1) have been implicated in the pathophysiology of this disease. Using a high-throughput screening assay expressing mutant G93A SOD1, two bioactive...

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Main Authors: Chen, Tian, Benmohamed, Radhia, Arvanites, Anthony C., Ranaivo, Hantamalala Ralay, Morimoto, Richard I., Ferrante, Robert J., Watterson, D. Martin, Kirsch, Donald R., Silverman, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014451/
https://ncbi.nlm.nih.gov/pubmed/21095130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.10.052
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