Identification of Compounds Protective Against G93A SOD1 Toxicity for the Treatment of Amyotrophic Lateral Sclerosis

OBJECTIVE: The underlying cause of amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disorder, remains unknown. However, there is strong evidence that one pathophysiological mechanism, toxic protein misfolding and/or aggregation, may trigger motor neuron dysfunction and loss. Sinc...

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Detalhes bibliográficos
Publicado no:Amyotroph Lateral Scler
Main Authors: Benmohamed, Radhia, Arvanites, Anthony C., Kim, Jinho, Ferrante, Robert J., Silverman, Richard B., Morimoto, Richard I., Kirsch, Donald R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8131116/
https://ncbi.nlm.nih.gov/pubmed/21073276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/17482968.2010.522586
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