Arylazanylpyrazolone derivatives as inhibitors of mutant superoxide dismutase 1-dependent protein aggregation for the treatment of amyotrophic lateral sclerosis

The arylsulfanyl- and aryloxanylpyrazolone scaffolds previously were reported to inhibit Cu/Zn superoxide dismutase 1 dependent protein aggregation and to extend survival in the ALS mouse model. However, further evaluation of these compounds indicated weak pharmacokinetic properties and a relatively...

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Main Authors: Zhang, Yinan, Benmohamed, Radhia, Huang, He, Chen, Tian, Voisine, Cindy, Morimoto, Richard I., Kirsch, Donald R., Silverman, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3627359/
https://ncbi.nlm.nih.gov/pubmed/23445362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400079a
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