Mutant Superoxide Dismutase 1 Forms Aggregates in the Brain Mitochondrial Matrix of Amyotrophic Lateral Sclerosis Mice

An increasing body of evidence suggests that mitochondrial dysfunction plays an important role in the pathogenesis of familial amyotrophic lateral sclerosis associated with “gain of function” mutations in Cu/Zn superoxide dismutase 1 (SOD1). SOD1 is mostly a cytosolic protein, but a portion of SOD1...

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Detalles Bibliográficos
Publicado en:J Neurosci
Main Authors: Vijayvergiya, Chetan, Beal, M. Flint, Buck, Jochen, Manfredi, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2005
Assuntos:
Neurobiology of Disease
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725162/
https://ncbi.nlm.nih.gov/pubmed/15758154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4385-04.2005
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