Mutant superoxide dismutase aggregates from human spinal cord transmit amyotrophic lateral sclerosis

Motor neurons containing aggregates of superoxide dismutase 1 (SOD1) are hallmarks of amyotrophic lateral sclerosis (ALS) caused by mutations in the gene encoding SOD1. We have previously reported that two strains of mutant human (h) SOD1 aggregates (denoted A and B) can arise in hSOD1-transgenic mo...

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Bibliographic Details
Published in:Acta Neuropathol
Main Authors: Ekhtiari Bidhendi, Elaheh, Bergh, Johan, Zetterström, Per, Forsberg, Karin, Pakkenberg, Bente, Andersen, Peter M., Marklund, Stefan L., Brännström, Thomas
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2018
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6280858/
https://ncbi.nlm.nih.gov/pubmed/30284034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-018-1915-y
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