Overloading of Stable and Exclusion of Unstable Human Superoxide Dismutase-1 Variants in Mitochondria of Murine Amyotrophic Lateral Sclerosis Models

Mutants of human superoxide dismutase-1 (hSOD1) cause amyotrophic lateral sclerosis (ALS), and mitochondria are thought to be primary targets of the cytotoxic action. The high expression rates of hSOD1s in transgenic ALS models give high levels of the stable mutants G93A and D90A as well as the wild...

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Publicado no:J Neurosci
Main Authors: Bergemalm, Daniel, Jonsson, P. Andreas, Graffmo, Karin S., Andersen, Peter M., Brännström, Thomas, Rehnmark, Anna, Marklund, Stefan L.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673995/
https://ncbi.nlm.nih.gov/pubmed/16624935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5461-05.2006
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