Two superoxide dismutase prion strains transmit amyotrophic lateral sclerosis–like disease

Amyotrophic lateral sclerosis (ALS) is an adult-onset degeneration of motor neurons that is commonly caused by mutations in the gene encoding superoxide dismutase 1 (SOD1). Both patients and Tg mice expressing mutant human SOD1 (hSOD1) develop aggregates of unknown importance. In Tg mice, 2 differen...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Bidhendi, Elaheh Ekhtiari, Bergh, Johan, Zetterström, Per, Andersen, Peter M., Marklund, Stefan L., Brännström, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887173/
https://ncbi.nlm.nih.gov/pubmed/27140399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI84360
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