Peripheral administration of SOD1 aggregates does not transmit pathogenic aggregation to the CNS of SOD1 transgenic mice

The deposition of aggregated proteins is a common neuropathological denominator for neurodegenerative disorders. Experimental evidence suggests that disease propagation involves prion-like mechanisms that cause the spreading of template-directed aggregation of specific disease-associated proteins. I...

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Vydáno v:Acta Neuropathol Commun
Hlavní autoři: Keskin, Isil, Ekhtiari Bidhendi, Elaheh, Marklund, Matthew, Andersen, Peter M., Brännström, Thomas, Marklund, Stefan L., Nordström, Ulrika
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2021
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8220797/
https://ncbi.nlm.nih.gov/pubmed/34158126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-021-01211-9
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