Aggregate-selective antibody attenuates seeded aggregation but not spontaneously evolving disease in SOD1 ALS model mice

Increasing evidence suggests that propagation of the motor neuron disease amyotrophic lateral sclerosis (ALS) involves the pathogenic aggregation of disease-associated proteins that spread in a prion-like manner. We have identified two aggregate strains of human superoxide dismutase 1 (hSOD1) that a...

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Dades bibliogràfiques
Publicat a:Acta Neuropathol Commun
Autors principals: Lehmann, Manuela, Marklund, Matthew, Bolender, Anna-Lena, Bidhendi, Elaheh E., Zetterström, Per, Andersen, Peter M., Brännström, Thomas, Marklund, Stefan L., Gilthorpe, Jonathan D., Nordström, Ulrika
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488686/
https://ncbi.nlm.nih.gov/pubmed/32928301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01032-2
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