Aggregate-selective antibody attenuates seeded aggregation but not spontaneously evolving disease in SOD1 ALS model mice

Increasing evidence suggests that propagation of the motor neuron disease amyotrophic lateral sclerosis (ALS) involves the pathogenic aggregation of disease-associated proteins that spread in a prion-like manner. We have identified two aggregate strains of human superoxide dismutase 1 (hSOD1) that a...

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Publicado en:Acta Neuropathol Commun
Autores principales: Lehmann, Manuela, Marklund, Matthew, Bolender, Anna-Lena, Bidhendi, Elaheh E., Zetterström, Per, Andersen, Peter M., Brännström, Thomas, Marklund, Stefan L., Gilthorpe, Jonathan D., Nordström, Ulrika
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488686/
https://ncbi.nlm.nih.gov/pubmed/32928301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01032-2
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