Aggregate-selective antibody attenuates seeded aggregation but not spontaneously evolving disease in SOD1 ALS model mice

Increasing evidence suggests that propagation of the motor neuron disease amyotrophic lateral sclerosis (ALS) involves the pathogenic aggregation of disease-associated proteins that spread in a prion-like manner. We have identified two aggregate strains of human superoxide dismutase 1 (hSOD1) that a...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Acta Neuropathol Commun
Päätekijät: Lehmann, Manuela, Marklund, Matthew, Bolender, Anna-Lena, Bidhendi, Elaheh E., Zetterström, Per, Andersen, Peter M., Brännström, Thomas, Marklund, Stefan L., Gilthorpe, Jonathan D., Nordström, Ulrika
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2020
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488686/
https://ncbi.nlm.nih.gov/pubmed/32928301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01032-2
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