Aggregate-selective antibody attenuates seeded aggregation but not spontaneously evolving disease in SOD1 ALS model mice

Increasing evidence suggests that propagation of the motor neuron disease amyotrophic lateral sclerosis (ALS) involves the pathogenic aggregation of disease-associated proteins that spread in a prion-like manner. We have identified two aggregate strains of human superoxide dismutase 1 (hSOD1) that a...

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Vydáno v:Acta Neuropathol Commun
Hlavní autoři: Lehmann, Manuela, Marklund, Matthew, Bolender, Anna-Lena, Bidhendi, Elaheh E., Zetterström, Per, Andersen, Peter M., Brännström, Thomas, Marklund, Stefan L., Gilthorpe, Jonathan D., Nordström, Ulrika
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488686/
https://ncbi.nlm.nih.gov/pubmed/32928301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01032-2
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