Impaired Extracellular Secretion of Mutant Superoxide Dismutase 1 Associates with Neurotoxicity in Familial Amyotrophic Lateral Sclerosis

Mutations in the intracellular metalloenzyme superoxide dismutase 1 (SOD1) are linked to neurotoxicity in familial amyotrophic lateral sclerosis (ALS) by an unclear mechanism. Golgi fragmentation and endoplasmic reticulum stress are early hallmarks of spinal motor neuron pathology in transgenic mice...

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Опубликовано в: :J Neurosci
Главные авторы: Turner, Bradley J., Atkin, Julie D., Farg, Manal A., Zang, Da Wei, Rembach, Alan, Lopes, Elizabeth C., Patch, Justin D., Hill, Andrew F., Cheema, Surindar S.
Формат: Artigo
Язык:Inglês
Опубликовано: Society for Neuroscience 2005
Предметы:
Neurobiology of Disease
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725218/
https://ncbi.nlm.nih.gov/pubmed/15634772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4253-04.2005
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