Impaired Extracellular Secretion of Mutant Superoxide Dismutase 1 Associates with Neurotoxicity in Familial Amyotrophic Lateral Sclerosis

Mutations in the intracellular metalloenzyme superoxide dismutase 1 (SOD1) are linked to neurotoxicity in familial amyotrophic lateral sclerosis (ALS) by an unclear mechanism. Golgi fragmentation and endoplasmic reticulum stress are early hallmarks of spinal motor neuron pathology in transgenic mice...

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Bibliografiska uppgifter
I publikationen:J Neurosci
Huvudupphovsmän: Turner, Bradley J., Atkin, Julie D., Farg, Manal A., Zang, Da Wei, Rembach, Alan, Lopes, Elizabeth C., Patch, Justin D., Hill, Andrew F., Cheema, Surindar S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Society for Neuroscience 2005
Ämnen:
Neurobiology of Disease
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725218/
https://ncbi.nlm.nih.gov/pubmed/15634772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4253-04.2005
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