Tertiary amine pyrazolones and their salts as inhibitors of mutant superoxide dismutase 1-dependent protein aggregation for the treatment of amyotrophic lateral sclerosis

Pyrazolone derivatives have previously been found to be inhibitors of Cu/Zn superoxide dismutase 1 (SOD1)-dependent protein aggregation, which extended survival of an amyotrophic lateral sclerosis (ALS) mouse model. On the basis of ADME analysis, we describe herein a new series of tertiary amine-con...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Zhang, Yinan, Zhao, Kevin Tianmeng, Fox, Susan G., Kim, Jinho, Kirsch, Donald R., Ferrante, Robert J., Morimoto, Richard I., Silverman, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537347/
https://ncbi.nlm.nih.gov/pubmed/26186011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00561
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