Distinct Regions of the Large Extracellular Domain of Tetraspanin CD9 Are Involved in the Control of Human Multinucleated Giant Cell Formation

Tekijä Hulme, Rachel S., Higginbottom, Adrian, Palmer, John, Partridge, Lynda J., Monk, Peter N.
Julkaisussa PLoS One (2014)

An in vitro screening cascade to identify neuroprotective antioxidants in ALS

Tekijä Barber, Siân C., Higginbottom, Adrian, Mead, Richard J., Barber, Stuart, Shaw, Pamela J.
Julkaistu 2009

CD81 Is Required for Hepatitis C Virus Glycoprotein-Mediated Viral Infection

Tekijä Zhang, Jie, Randall, Glenn, Higginbottom, Adrian, Monk, Peter, Rice, Charles M., McKeating, Jane A.
Julkaistu 2004

Viral Delivery of Antioxidant Genes as a Therapeutic Strategy in Experimental Models of Amyotrophic Lateral Sclerosis

Tekijä Nanou, Aikaterini, Higginbottom, Adrian, Valori, Chiara F, Wyles, Matthew, Ning, Ke, Shaw, Pamela, Azzouz, Mimoun
Julkaistu 2013

Dysregulation of astrocyte–motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis

Tekijä Ferraiuolo, Laura, Higginbottom, Adrian, Heath, Paul R., Barber, Sian, Greenald, David, Kirby, Janine, Shaw, Pamela J.
Julkaistu 2011

A new zebrafish model produced by TILLING of SOD1-related amyotrophic lateral sclerosis replicates key features of the disease and represents a tool for in vivo therapeutic screeni...

Tekijä Da Costa, Marc M. J., Allen, Claire E., Higginbottom, Adrian, Ramesh, Tennore, Shaw, Pamela J., McDermott, Christopher J.
Julkaistu 2014

Characterisation of receptor binding by the chemotaxis inhibitory protein of Staphylococcus aureus and the effects of the host immune response

Tekijä Wright, Andrew J., Higginbottom, Adrian, Philippe, Didier, Upadhyay, Abhishek, Bagby, Stefan, Read, Robert C., Monk, Peter N., Partridge, Lynda J.
Julkaistu 2007

Simultaneous and independent detection of C9ORF72 alleles with low and high number of GGGGCC repeats using an optimised protocol of Southern blot hybridisation

Tekijä Buchman, Vladimir L, Cooper-Knock, Johnathan, Connor-Robson, Natalie, Higginbottom, Adrian, Kirby, Janine, Razinskaya, Olga D, Ninkina, Natalia, Shaw, Pamela J
Julkaistu 2013

Characterization of Hepatitis C Virus E2 Glycoprotein Interaction with a Putative Cellular Receptor, CD81

Tekijä Flint, Mike, Maidens, Catherine, Loomis-Price, Larry D., Shotton, Christine, Dubuisson, Jean, Monk, Peter, Higginbottom, Adrian, Levy, Shoshana, McKeating, Jane A.
Julkaistu 1999

THE ROLE OF THE N-TERMINAL DOMAIN OF THE COMPLEMENT FRAGMENT RECEPTOR, C5L2, IN LIGAND BINDING

Tekijä Scola, Anne-Marie, Higginbottom, Adrian, Partridge, Lynda J, Reid, Robert C., Woodruff, Trent, Taylor, Stephen M., Fairlie, David P., Monk, Peter N
Julkaistu 2006

Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features

Tekijä Shaw, Matthew P., Higginbottom, Adrian, McGown, Alexander, Castelli, Lydia M., James, Evlyn, Hautbergue, Guillaume M., Shaw, Pamela J., Ramesh, Tennore M.
Julkaisussa Acta Neuropathol Commun (2018)

Recombinant Extracellular Domains of Tetraspanin Proteins Are Potent Inhibitors of the Infection of Macrophages by Human Immunodeficiency Virus Type 1

Tekijä Ho, Siu-Hong, Martin, Francine, Higginbottom, Adrian, Partridge, Lynda J., Parthasarathy, Varadarajan, Moseley, Gregory W., Lopez, Peter, Cheng-Mayer, Cecilia, Monk, Peter N.
Julkaistu 2006

C9ORF72 transcription in a frontotemporal dementia case with two expanded alleles

Tekijä Cooper-Knock, Johnathan, Higginbottom, Adrian, Connor-Robson, Natalie, Bayatti, Nadhim, Bury, Joanna J., Kirby, Janine, Ninkina, Natalia, Buchman, Vladimir L., Shaw, Pamela J.
Julkaistu 2013

Distinct roles for tetraspanins CD9, CD63 and CD81 in the formation of multinucleated giant cells

Tekijä Parthasarathy, Varadarajan, Martin, Francine, Higginbottom, Adrian, Murray, Helen, Moseley, Gregory W, Read, Robert C, Mal, Gorakh, Hulme, Rachel, Monk, Peter N, Partridge, Lynda J
Julkaistu 2009

A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive...

Tekijä Simpson, Julie E., Ince, Paul G., Matthews, Fiona E., Shaw, Pamela J., Heath, Paul R., Brayne, Carol, Garwood, Claire, Higginbottom, Adrian, Wharton, Stephen B.
Julkaisussa Neuropathol Appl Neurobiol (2015)

Identification of Amino Acid Residues in CD81 Critical for Interaction with Hepatitis C Virus Envelope Glycoprotein E2

Tekijä Higginbottom, Adrian, Quinn, Elizabeth R., Kuo, Chiung-Chi, Flint, Mike, Wilson, Louise H., Bianchi, Elisabetta, Nicosia, Alfredo, Monk, Peter N., McKeating, Jane A., Levy, Shoshana
Julkaistu 2000

C9ORF72 GGGGCC Expanded Repeats Produce Splicing Dysregulation which Correlates with Disease Severity in Amyotrophic Lateral Sclerosis

Tekijä Cooper-Knock, Johnathan, Bury, Joanna J., Heath, Paul R, Wyles, Matthew, Higginbottom, Adrian, Gelsthorpe, Catherine, Highley, J. Robin, Hautbergue, Guillaume, Rattray, Magnus, Kirby, Janine, Shaw, Pamela J.
Julkaisussa PLoS One (2015)

Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy

Tekijä Cooper-Knock, Johnathan, Higginbottom, Adrian, Stopford, Matthew J., Highley, J. Robin, Ince, Paul G., Wharton, Stephen B., Pickering-Brown, Stuart, Kirby, Janine, Hautbergue, Guillaume M., Shaw, Pamela J.
Julkaisussa Acta Neuropathol (2015)

TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons

Tekijä Vogt, Miriam A., Ehsaei, Zahra, Knuckles, Philip, Higginbottom, Adrian, Helmbrecht, Michaela S., Kunath, Tilo, Eggan, Kevin, Williams, Luis A., Shaw, Pamela J., Wurst, Wolfgang, Floss, Thomas, Huber, Andrea B., Taylor, Verdon
Julkaisussa Sci Rep (2018)

S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis()

Tekijä Mead, Richard J., Higginbottom, Adrian, Allen, Scott P., Kirby, Janine, Bennett, Ellen, Barber, Siân C., Heath, Paul R., Coluccia, Antonio, Patel, Neelam, Gardner, Iain, Brancale, Andrea, Grierson, Andrew J., Shaw, Pamela J.
Julkaistu 2013