Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy

GGGGCC repeat expansions of C9ORF72 represent the most common genetic variant of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. We and others have proposed that RNA transcribed from the repeat sequence is toxic via sequestration of RNA-binding factors. Both GGGGCC-repeat (sense) an...

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Vydáno v:Acta Neuropathol
Hlavní autoři: Cooper-Knock, Johnathan, Higginbottom, Adrian, Stopford, Matthew J., Highley, J. Robin, Ince, Paul G., Wharton, Stephen B., Pickering-Brown, Stuart, Kirby, Janine, Hautbergue, Guillaume M., Shaw, Pamela J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2015
Témata:
Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468790/
https://ncbi.nlm.nih.gov/pubmed/25943887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-015-1429-9
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