THE ROLE OF THE N-TERMINAL DOMAIN OF THE COMPLEMENT FRAGMENT RECEPTOR, C5L2, IN LIGAND BINDING

C5L2 is a new cellular receptor found to interact with the human anaphylatoxins complement factor C5a and its C-terminal cleavage product C5a des Arg. The classical human C5a receptor (C5aR) preferentially binds C5a, with a 10-100-fold lower affinity for C5a des Arg. In contrast, C5L2 binds both lig...

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Detalhes bibliográficos
Main Authors: Scola, Anne-Marie, Higginbottom, Adrian, Partridge, Lynda J, Reid, Robert C., Woodruff, Trent, Taylor, Stephen M., Fairlie, David P., Monk, Peter N
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873560/
https://ncbi.nlm.nih.gov/pubmed/17158873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M609178200
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