Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features

A hexanucleotide repeat expansion (HRE) within the chromosome 9 open reading frame 72 (C9orf72) gene is the most prevalent cause of amyotrophic lateral sclerosis/fronto-temporal dementia (ALS/FTD). Current evidence suggests HREs induce neurodegeneration through accumulation of RNA foci and/or dipept...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Shaw, Matthew P., Higginbottom, Adrian, McGown, Alexander, Castelli, Lydia M., James, Evlyn, Hautbergue, Guillaume M., Shaw, Pamela J., Ramesh, Tennore M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6240957/
https://ncbi.nlm.nih.gov/pubmed/30454072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-018-0629-7
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