A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort

AIMS: Population‐based studies have shown that approximately 20% of the ageing population (aged 65 years and over) with dementia have little or no classical Alzheimer‐type neuropathology. Cumulative DNA damage and a reduced capacity of DNA repair may result in neuronal dysfunction and contribute to...

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Pubblicato in:Neuropathol Appl Neurobiol
Autori principali: Simpson, Julie E., Ince, Paul G., Matthews, Fiona E., Shaw, Pamela J., Heath, Paul R., Brayne, Carol, Garwood, Claire, Higginbottom, Adrian, Wharton, Stephen B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2015
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861215/
https://ncbi.nlm.nih.gov/pubmed/25443110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nan.12202
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