Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain

Type 2 diabetes mellitus (T2D), characterised by peripheral insulin resistance, is a risk factor for dementia. In addition to its contribution to small and large vessel disease, T2D may directly damage cells of the brain neurovascular unit. In this study, we investigated the transcriptomic changes i...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Bury, Joanna J., Chambers, Annabelle, Heath, Paul R., Ince, Paul G., Shaw, Pamela J., Matthews, Fiona E., Brayne, Carol, Simpson, Julie E., Wharton, Stephen B.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7788898/
https://ncbi.nlm.nih.gov/pubmed/33407907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01109-y
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