Neuronal DNA damage response‐associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer‐type pathology

AIMS: Oxidative damage and an associated DNA damage response (DDR) are evident in mild cognitive impairment and early Alzheimer's disease, suggesting that neuronal dysfunction resulting from oxidative DNA damage may account for some of the cognitive impairment not fully explained by Alzheimer‐t...

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Pubblicato in:Neuropathol Appl Neurobiol
Autori principali: Simpson, Julie E., Ince, Paul G., Minett, Thais, Matthews, Fiona E., Heath, Paul R., Shaw, Pamela J., Goodall, Emily, Garwood, Claire J., Ratcliffe, Laura E., Brayne, Carol, Rattray, Magnus, Wharton, Stephen B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2015
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5102584/
https://ncbi.nlm.nih.gov/pubmed/26095650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nan.12252
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