The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain

The accumulation of reactive oxygen species leading to oxidative damage and cell death plays an important role in a number of neurodegenerative disorders. FOXO3a, the main isoform of FOXO transcription factors, mediates the cellular response to oxidative stress by regulating the expression of genes...

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Dettagli Bibliografici
Pubblicato in:Neurosci Lett
Autori principali: Fluteau, Adeline, Ince, Paul G., Minett, Thais, Matthews, Fiona E., Brayne, Carol, Garwood, Claire J., Ratcliffe, Laura E., Morgan, Sarah, Heath, Paul R., Shaw, Pamela J., Wharton, Stephen B., Simpson, Julie E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier Scientific Publishers Ireland 2015
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674771/
https://ncbi.nlm.nih.gov/pubmed/26455863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2015.10.001
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