ALS/FTD‐associated FUS activates GSK‐3β to disrupt the VAPB–PTPIP51 interaction and ER–mitochondria associations

Defective FUS metabolism is strongly associated with amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD), but the mechanisms linking FUS to disease are not properly understood. However, many of the functions disrupted in ALS/FTD are regulated by signalling between the endoplasmic ret...

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Bibliografiska uppgifter
I publikationen:EMBO Rep
Huvudupphovsmän: Stoica, Radu, Paillusson, Sébastien, Gomez‐Suaga, Patricia, Mitchell, Jacqueline C, Lau, Dawn HW, Gray, Emma H, Sancho, Rosa M, Vizcay‐Barrena, Gema, De Vos, Kurt J, Shaw, Christopher E, Hanger, Diane P, Noble, Wendy, Miller, Christopher CJ
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2016
Ämnen:
Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007559/
https://ncbi.nlm.nih.gov/pubmed/27418313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201541726
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