α-Synuclein binds to the ER–mitochondria tethering protein VAPB to disrupt Ca(2+) homeostasis and mitochondrial ATP production

α-Synuclein is strongly linked to Parkinson’s disease but the molecular targets for its toxicity are not fully clear. However, many neuronal functions damaged in Parkinson’s disease are regulated by signalling between the endoplasmic reticulum (ER) and mitochondria. This signalling involves close ph...

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Detaylı Bibliyografya
Yayımlandı:Acta Neuropathol
Asıl Yazarlar: Paillusson, Sébastien, Gomez-Suaga, Patricia, Stoica, Radu, Little, Daniel, Gissen, Paul, Devine, Michael J., Noble, Wendy, Hanger, Diane P., Miller, Christopher C. J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Springer Berlin Heidelberg 2017
Konular:
Original Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5486644/
https://ncbi.nlm.nih.gov/pubmed/28337542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-017-1704-z
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