α-Synuclein binds to the ER–mitochondria tethering protein VAPB to disrupt Ca(2+) homeostasis and mitochondrial ATP production

α-Synuclein is strongly linked to Parkinson’s disease but the molecular targets for its toxicity are not fully clear. However, many neuronal functions damaged in Parkinson’s disease are regulated by signalling between the endoplasmic reticulum (ER) and mitochondria. This signalling involves close ph...

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Publicat a:Acta Neuropathol
Autors principals: Paillusson, Sébastien, Gomez-Suaga, Patricia, Stoica, Radu, Little, Daniel, Gissen, Paul, Devine, Michael J., Noble, Wendy, Hanger, Diane P., Miller, Christopher C. J.
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2017
Matèries:
Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5486644/
https://ncbi.nlm.nih.gov/pubmed/28337542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-017-1704-z
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