How could Parkin-mediated ubiquitination of mitofusin promote mitophagy?

по Ziviani, Elena, Whitworth, Alexander J.
Опубликовано 2010

SREBF1 links lipogenesis to mitophagy and sporadic Parkinson disease

по Ivatt, Rachael M, Whitworth, Alexander J
Опубликовано 2014

The many faces of mitophagy

по Ivatt, Rachael M, Whitworth, Alexander J
Опубликовано в: EMBO Rep (2014)

Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin

по Ziviani, Elena, Tao, Ran N., Whitworth, Alexander J.
Опубликовано 2010

The STING pathway does not contribute to behavioural or mitochondrial phenotypes in Drosophila Pink1/parkin or mtDNA mutator models

по Lee, Juliette J., Andreazza, Simonetta, Whitworth, Alexander J.
Опубликовано в: Sci Rep (2020)

VPS35 pathogenic mutations confer no dominant toxicity but partial loss of function in Drosophila and genetically interact with parkin

по Malik, Bilal R., Godena, Vinay K., Whitworth, Alexander J.
Опубликовано в: Hum Mol Genet (2015)

Drosophila phosphatidylinositol-4 kinase fwd promotes mitochondrial fission and can suppress Pink1/parkin phenotypes

по Terriente-Felix, Ana, Wilson, Emma L., Whitworth, Alexander J.
Опубликовано в: PLoS Genet (2020)

Superoxide Radical Dismutation as New Therapeutic Strategy in Parkinson’s Disease

по De Lazzari, Federica, Bubacco, Luigi, Whitworth, Alexander J, Bisaglia, Marco
Опубликовано в: Aging Dis (2018)

Antioxidant Therapy in Parkinson’s Disease: Insights from Drosophila melanogaster

по De Lazzari, Federica, Sandrelli, Federica, Whitworth, Alexander J., Bisaglia, Marco
Опубликовано в: Antioxidants (Basel) (2020)

Axonal transport defects are a common phenotype in Drosophila models of ALS

по Baldwin, Katie R., Godena, Vinay K., Hewitt, Victoria L., Whitworth, Alexander J.
Опубликовано в: Hum Mol Genet (2016)

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss

по Tain, Luke S, Mortiboys, Heather, Tao, Ran N, Ziviani, Elena, Bandmann, Oliver, Whitworth, Alexander J
Опубликовано 2009

DJ-1: A promising therapeutic candidate for ischemia-reperfusion injury

по De Lazzari, Federica, Prag, Hiran A., Gruszczyk, Anja V., Whitworth, Alexander J., Bisaglia, Marco
Опубликовано в: Redox Biol (2021)

Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy

по Ivatt, Rachael M., Sanchez-Martinez, Alvaro, Godena, Vinay K., Brown, Stephen, Ziviani, Elena, Whitworth, Alexander J.
Опубликовано 2014

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

по Greene, Jessica C., Whitworth, Alexander J., Kuo, Isabella, Andrews, Laurie A., Feany, Mel B., Pallanck, Leo J.
Опубликовано 2003

Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease

по Whitworth, Alexander J., Theodore, Dorothy A., Greene, Jessica C., Beneš, Helen, Wes, Paul D., Pallanck, Leo J.
Опубликовано 2005

Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson’s disease factors Pink1 and Parkin

по Whitworth, Alexander J., Lee, Jeffrey R., Ho, Venus M.-W., Flick, Robert, Chowdhury, Ruhena, McQuibban, G. Angus
Опубликовано 2008

The Complex I Subunit NDUFA10 Selectively Rescues Drosophila pink1 Mutants through a Mechanism Independent of Mitophagy

по Pogson, Joe H., Ivatt, Rachael M., Sanchez-Martinez, Alvaro, Tufi, Roberta, Wilson, Emma, Mortiboys, Heather, Whitworth, Alexander J.
Опубликовано в: PLoS Genet (2014)

Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models

по Sanchez-Martinez, Alvaro, Beavan, Michelle, Gegg, Matthew E., Chau, Kai-Yin, Whitworth, Alexander J., Schapira, Anthony H. V.
Опубликовано в: Sci Rep (2016)

The PINK1/Parkin pathway regulates mitochondrial morphology

по Poole, Angela C., Thomas, Ruth E., Andrews, Laurie A., McBride, Heidi M., Whitworth, Alexander J., Pallanck, Leo J.
Опубликовано 2008

Modeling Pathogenic Mutations of Human Twinkle in Drosophila Suggests an Apoptosis Role in Response to Mitochondrial Defects

по Sanchez-Martinez, Alvaro, Calleja, Manuel, Peralta, Susana, Matsushima, Yuichi, Hernandez-Sierra, Rosana, Whitworth, Alexander J., Kaguni, Laurie S., Garesse, Rafael
Опубликовано 2012