The PINK1/Parkin pathway regulates mitochondrial morphology

Loss-of-function mutations in the PTEN-induced kinase 1 (PINK1) or parkin genes, which encode a mitochondrially localized serine/threonine kinase and a ubiquitin-protein ligase, respectively, result in recessive familial forms of Parkinsonism. Genetic studies in Drosophila indicate that PINK1 acts u...

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Bibliografiske detaljer
Main Authors: Poole, Angela C., Thomas, Ruth E., Andrews, Laurie A., McBride, Heidi M., Whitworth, Alexander J., Pallanck, Leo J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234197/
https://ncbi.nlm.nih.gov/pubmed/18230723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709336105
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