The Mitochondrial Fusion-Promoting Factor Mitofusin Is a Substrate of the PINK1/Parkin Pathway

Loss-of-function mutations in the PINK1 or parkin genes result in recessive heritable forms of parkinsonism. Genetic studies of Drosophila orthologs of PINK1 and parkin indicate that PINK1, a mitochondrially targeted serine/threonine kinase, acts upstream of Parkin, a cytosolic ubiquitin-protein lig...

Full description

Saved in:
Bibliographic Details
Main Authors: Poole, Angela C., Thomas, Ruth E., Yu, Selina, Vincow, Evelyn S., Pallanck, Leo
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2850930/
https://ncbi.nlm.nih.gov/pubmed/20383334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010054
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items