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The PINK1–Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo
The accumulation of damaged mitochondria has been proposed as a key factor in aging and the pathogenesis of many common age-related diseases, including Parkinson disease (PD). Recently, in vitro studies of the PD-related proteins Parkin and PINK1 have found that these factors act in a common pathway...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3631677/ https://ncbi.nlm.nih.gov/pubmed/23509287 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1221132110 |
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