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Phosphorylation of kinesin light chain 1 at serine 460 modulates binding and trafficking of calsyntenin-1

Kinesin light chain 1 (KLC1) binds to the intracellular cytoplasmic domain of the type-1 membrane-spanning protein calsyntenin-1 (also known as alcadein-α) to mediate transport of a subset of vesicles. Here, we identify serine 460 in KLC1 (KLC1ser460) as a phosphorylation site and show that mutation...

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Bibliographische Detailangaben
Hauptverfasser: Vagnoni, Alessio, Rodriguez, Lilia, Manser, Catherine, De Vos, Kurt J., Miller, Christopher C. J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Company of Biologists 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056604/
https://ncbi.nlm.nih.gov/pubmed/21385839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.075168
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